Trends in Immunology

February, 2012
Volume 33, Issue 2

Volume 33, Issue 2

T cell exhaustion, i.e. the loss of T cell function and deletion of virus-specific T cell responses, is a typical feature of chronic viral infection. In contrast, infection with cytomegalovirus (CMV), which is evident in 60–80% of the population at 80 years old in the developed world, drives a very different T cell response. CMV-specific T cells adopt a memory-effector phenotype and are maintained or accumulate in a process named ``memory inflation''. On pages 84–90, O’Hara et al., examine the factors that contribute to memory inflation and discuss how CMV-specific T cells might affect immune responses in the elderly. They also consider the possibility of exploiting memory inflation in vaccine strategies to protect against infection and cancer. Cover image designed by Geraldine O’Hara, University of Oxford.

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Editorial Team

Editor
Elizabeth Thompson
Executive Editor, Immunology
Peter Lee
Journal Manager
Mia Schouten
Journal Administrator
Ria Otten and Patrick Scheffmann

Advisory Editorial Board

G. Anderson
R. Brink
F.R. Carbone
D.C. Doeuk
M.F. Flajnik
A. Iwasaki
J. Kipnis
B.N. Lambrecht
J.D. Lambris
A. Mantovani
L.M. Moretta
G.J.V.Nossal
P.S. Ohashi
L.A.J. O'Neill
R. M. Ransohoff
J. Ruland
S.F. Ziegler
K. Wood

Editorial Opportunity

Editor, Trends in Biochemical Sciences

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Announcements

Trends in Immunology welcomes Jürgen Ruland and Steven Ziegler to the Advisory Editorial Board.

About Trends in Immunology

Trends in Immunology publishes concise, lively and up-to-date articles that highlight advances in the diverse fields of immunology. Review and Opinion articles form the basis of each monthly issue. Review articles objectively chronicle recent and important developments in a field. Opinion articles provide a forum for debate and hypothesis. Articles are generally invited by the Editor but proposals are welcome. Proposals should be sent to the editor (immunology@elsevier.com), as a brief summary that includes key references.

Volume 33, Issue 2 | February 2012

Emerging cellular networks for regulation of T follicular helper cells
Cecile King, and Jonathan Sprent

CD169+ macrophages at the crossroads of antigen presentation
Luisa Martinez-Pomares, and Siamon Gordon

New directions in the basic and translational biology of interleukin-27
Elia D. Tait Wojno, and Christopher A. Hunter

For a complete list of articles in this issue, click here.

Featured Topic: Neutrophils

For more featured topics click here.

Neutrophils in tuberculosis: friend or foe??
David M. Lowe, Paul S. Redford, Robert J. Wilkinson, Anne O’Garra, Adrian R. Martineau

Emerging mechanisms of neutrophil recruitment across endothelium
Marcie R. Williams, Verónica Azcutia, Gail Newton, Pilar Alcaide, Francis W. Luscinskas

Neutrophils cascading their way to inflammation
Christian D. Sadik, Nancy D. Kim, Andrew D. Luster

Neutrophil clearance: When the party is over, clean-up begins
Donna L. Bratton, Peter M. Henson

Regulating neutrophil apoptosis: New players enter the game
Véronique Witko-Sarsat, Magali Pederzoli-Ribeil, Emilio Hirsh, Silvano Sozzani, Marco A. Cassatella

Neutrophil kinetics in health and disease
Charlotte Summers, Sara M. Rankin, Alison M. Condliffe, Nanak Singh, A. Michael Peters, Edwin R. Chilvers