February, 2012
Volume 28, Issue 2

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Volume 28, Issue 2

Although inbred mouse strains have been the premier model organism used in biomedical research, genome-wide association studies (GWAS) have seldom been successful at identifying genes involved in clinically relevant traits. On pages 62–69 of this issue, Gary Peltz and colleagues describe a new computational approach which, when used in the context of other `omics' data, can substantially improve the prognosis of mice genetic association studies for biomedical discovery.

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    Masatoshi Takeichi
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Featured Article

A complex ‘mRNA degradation code’ controls gene expression during animal development
Claudio R. Alonso
10.1016/j.tig.2011.10.005
Abstract | |

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Volume 28, Issue 2 | February 2012


Featured Article  

A complex ‘mRNA degradation code’ controls gene expression during animal development
Claudio R. Alonso

*FREE DOWNLOAD*

Issue Highlights

De novo mRNP quality control goes regulatory
Oliver Mühlemann and Torben Heick Jensen
Viral evolution in deep time: lentiviruses and mammals
Robert J. Gifford

For a complete list of articles in this issue, click here.


Most Read Articles RSS Icon Article Feed

These are the five most downloaded papers for the 30 days preceding February 4, 2012. See full list of most read articles

A complex ‘mRNA degradation code’ controls gene expression during animal development
Claudio R. Alonso
10.1016/j.tig.2011.10.005
Summary | |
Viral evolution in deep time: lentiviruses and mammals
Robert J. Gifford
10.1016/j.tig.2011.11.003
Summary | |
The genomic impact of 100 million years of social evolution in seven ant species
Jürgen Gadau, Martin Helmkampf, Sanne Nygaard, Julien Roux, Daniel F. Simola, Chris R. Smith, Garret Suen, Yannick Wurm, Christopher D. Smith
10.1016/j.tig.2011.08.005
Summary | |
Epigenetic factors influencing resistance to nuclear reprogramming
Vincent Pasque, Jerome Jullien, Kei Miyamoto, Richard P. Halley-Stott, J.B. Gurdon
10.1016/j.tig.2011.08.002
Summary | |
De novo DNA methylation: a germ cell perspective
Sébastien A. Smallwood, Gavin Kelsey
10.1016/j.tig.2011.09.004
Summary | |